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<i>Bulbophyllum emarginatum<_i> (Finet) J. J. Smith

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (1) 5 alpha Reductase (8) 5-HT Receptor (8) Acetyl-CoA Carboxylase (1) Ack1 (1) Acyltransferase (1) ADAMTS (2) ADC Antibody (1) ADC Cytotoxin (40) ADC Linker (4) Adenosine Deaminase (1) Adenosine Receptor (5) Adenylate Cyclase (3) Adrenergic Receptor (18) AIM2 (2) Akt (7) Aldose Reductase (1) Amino Acid Derivatives (12) Aminoacyl-tRNA Synthetase (1) Aminopeptidase (1) AMPK (11) Amylases (3) Amyloid-β (11) Anaplastic lymphoma kinase (ALK) (3) Androgen Receptor (5) Angiotensin Receptor (26) Angiotensin-converting Enzyme (ACE) (33) Antibiotic (55) Antibody-Drug Conjugates (ADCs) (6) Apelin Receptor (APJ) (2) Apoptosis (204) Arenavirus (3) Arginase (5) Aryl Hydrocarbon Receptor (4) Atg8/LC3 (3) ATM/ATR (5) ATP Citrate Lyase (1) Aurora Kinase (5) Autophagy (72) Bacterial (98) Bcl-2 Family (5) BCL6 (2) Bcr-Abl (25) Beta-lactamase (1) Beta-secretase (3) Biochemical Assay Reagents (41) Bradykinin Receptor (1) Btk (6) c-Fms (1) c-Kit (2) c-Met/HGFR (2) Calcium Channel (22) CaMK (4) Carbonic Anhydrase (69) Carboxylesterase (1) Casein Kinase (5) Caspase (9) CaSR (1) Cathepsin (2) CCR (6) CD19 (5) CD20 (1) CD73 (1) CDK (24) Ceramidase (1) CFTR (2) Chloride Channel (1) Cholecystokinin Receptor (6) Cholinesterase (ChE) (17) CMV (1) Complement System (2) Constitutive Androstane Receptor (1) COX (13) CRAC Channel (1) CRFR (7) Cuproptosis (2) CXCR (14) Cyclic GMP-AMP Synthase (1) Cyclin G-associated Kinase (GAK) (1) Cyclophilin (1) Cytochrome P450 (11) Dengue virus (4) Deubiquitinase (6) DGK (2) Dihydrofolate reductase (DHFR) (1) Dipeptidyl Peptidase (2) DNA Methyltransferase (2) DNA Stain (1) DNA-PK (4) DNA/RNA Synthesis (50) Dopamine Receptor (3) Dopamine Transporter (5) Drug Metabolite (7) Drug-Linker Conjugates for ADC (33) Dynamin (11) DYRK (1) E1/E2/E3 Enzyme (5) E3 Ligase Ligand-Linker Conjugates (2) EAAT (1) EBV (1) EGFR (20) Elastase (3) Endogenous Metabolite (120) Endothelin Receptor (7) Enterovirus (1) Epigenetic Reader Domain (38) ERK (10) Estrogen Receptor/ERR (4) Eukaryotic Initiation Factor (eIF) (1) FAAH (1) Factor Xa (3) FAK (2) FAP (3) Farnesyl Transferase (7) Fatty Acid Synthase (FASN) (4) Ferroptosis (11) FGFR (6) Filovirus (3) Flavivirus (4) FLT3 (11) Fluorescent Dye (155) Formyl Peptide Receptor (FPR) (2) Free Fatty Acid Receptor (1) Fungal (35) FXR (2) G Protein-coupled Receptor Kinase (GRK) (2) G-quadruplex (1) GABA Receptor (3) GHSR (4) GLP Receptor (7) Glucokinase (1) Glucosidase (15) Glucosylceramide Synthase (GCS) (4) GLUT (3) Glutaminase (1) Glutathione Peroxidase (3) Glutathione S-transferase (1) Glyoxalase (GLO) (11) GlyT (4) GnRH Receptor (3) GPR109A (1) GPR119 (1) GSK-3 (7) Guanylate Cyclase (3) HBV (7) HCN Channel (1) HCV (9) HDAC (61) HIF/HIF Prolyl-Hydroxylase (5) Hippo (MST) (1) Histamine Receptor (3) Histone Acetyltransferase (2) Histone Demethylase (9) Histone Methyltransferase (12) HIV (38) HIV Integrase (1) HIV Protease (2) HMG-CoA Reductase (HMGCR) (2) HPV (3) HSP (9) HSV (2) ICMT (2) IFNAR (8) 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NOD-like Receptor (NLR) (6) Notch (2) NTPDase (1) Nucleoside Antimetabolite/Analog (47) Oct3/4 (2) Opioid Receptor (9) Organoid (16) Orthopoxvirus (2) Oxidative Phosphorylation (9) P-glycoprotein (4) P2X Receptor (3) P2Y Receptor (1) p38 MAPK (6) p62 (1) p97 (2) PACAP Receptor (6) PAK (1) Paraptosis (1) Parasite (47) PARP (5) PCSK9 (1) PD-1/PD-L1 (4) PDGFR (5) PDK-1 (1) PGE synthase (2) Phosphatase (3) Phosphodiesterase (PDE) (22) Phospholipase (2) PI3K (34) Pim (2) PKA (20) PKC (16) PKD (1) PKG (4) Platelet-activating Factor Receptor (PAFR) (1) Polo-like Kinase (PLK) (1) Potassium Channel (22) PPAR (6) Progesterone Receptor (1) Prostaglandin Receptor (9) PROTAC Linkers (2) PROTACs (58) Protease Activated Receptor (PAR) (4) Proteasome (25) Protein Arginine Deiminase (2) Protoporphyrinogen IX oxidase (1) PSMA (4) PTEN (1) Pyk2 (1) Pyruvate Kinase (1) Radionuclide-Drug Conjugates (RDCs) (3) Raf (2) Ras (11) Reactive Oxygen Species (26) Renin (4) RET (1) Reverse Transcriptase (3) RIP kinase (5) ROCK (9) ROR (1) ROS Kinase (3) RSV (3) SARS-CoV (14) Ser/Thr Protease (1) Serotonin Transporter (3) SF3B1 (1) SHMT (1) SHP2 (1) Sigma Receptor (1) Sirtuin (2) Small Interfering RNA (siRNA) (25) Sodium Channel (21) Somatostatin Receptor (4) SphK (4) Src (2) STAT (16) Stearoyl-CoA Desaturase (SCD) (1) Steroid Sulfatase (2) STING (13) Survivin (2) TAM Receptor (3) TGF-beta/Smad (7) TGF-β Receptor (31) Thrombin (2) TMV (2) TNF Receptor (21) Toll-like Receptor (TLR) (12) Topoisomerase (182) Transthyretin (TTR) (5) Trk Receptor (5) TROP2 (1) TRP Channel (7) TrxR (3) Tyrosinase (2) URAT1 (1) VD/VDR (4) VEGFR (11) Virus Protease (1) Wnt (3) Xanthine Oxidase (3) YAP (3) α-synuclein (2) β-catenin (2) γ-secretase (1)
By Research Areas:	Cancer (1131) Cardiovascular Disease (196) Endocrinology (76) Infection (270) Inflammation/Immunology (372) Metabolic Disease (198) Neurological Disease (264)
Click Chemistry:	TCO (1) DBCO (2) Azide (22) Tetrazine (1) Alkynes (13)
Oligonucleotides:	miRNA mimics (15) miRNA antagomirs (15) Nucleosides and their Analogs (32) Nucleoside Phosphoramidites (5) Flavoring Agents (1) miRNA inhibitors (15) Phospholipids (2) mRNA (3) Antisense Oligonucleotides (2) siRNAs (24) miRNA agomirs (15) MicroRNAs (60) Aptamers (5) Pre-designed siRNA Sets (24)

2566

Inhibitors & Agonists

Screening Libraries

141

Fluorescent Dye

Biochemical Assay Reagents

243

Peptides

MCE Kits

Inhibitory Antibodies

461

Natural
Products

397

Recombinant Proteins

Isotope-Labeled Compounds

148

Antibodies

Click Chemistry

134

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107721

(±)-J-113397	Opioid Receptor	Neurological Disease
(±)-J-113397 is a potent and selective non-peptidyl ORL1 receptor antagonist with a K_i of 1.8 nM for cloned human ORL1. J-113397 inhibited nociceptin/orphanin FQ-stimulated GTPγS binding to CHO cells expressing ORL1 with an IC₅₀ value of 5.3 nM. J-113397 can be used for researching the physiological roles of nociceptin/orphanin FQ .

HY-114072A

(S,S)-J-113397	Opioid Receptor	Neurological Disease
(S,S)-J-113397 is an isomer of J-113397 (HY-114072). J-113397 is an Opioid Receptor antagonist .

HY-155172

ZX-J-19j	Cyclophilin	Cancer
ZX-J-19j (Compound ZX-J-19j) is a cyclophilin J inhibitor. ZX-J-19j showes potent antitumor activity .

HY-163429

J-1149	TGF-β Receptor p38 MAPK	Inflammation/Immunology Cancer
J-1149 is a potent ALK5 inhibitor, with an IC₅₀ value of 0.017 μM. J-1149 also shows weak p38α MAP kinase inhibitory activity, with an IC₅₀ value of 0.435 μM. J-1149 can be used for liver fibrosis research .

HY-19301

J 104871 J-104135	Farnesyl Transferase	Cancer
J 104871 (J-104135) is a farnesyl pyrophosphate (FPP)-competitive farnesyltransferase (FTase) inhibitor. J 104871 inhibits rat brain FTase with an IC₅₀ of 3.9 nM in the presence of farnesyl pyrophosphate (FPP) .

HY-145855

J-1063	TGF-β Receptor	Inflammation/Immunology
J-1063 is a potent, selective and orally active ALK5 inhibitor with an IC₅₀ of 0.039 µM. J-1063 shows anti-fibrotic effect by the inhibition of inflammatory infiltration, collagen deposition, and hepatocytes necrosis. J-1063 has the potential for the research of liver fibrosis .

HY-129826

J-104129	mAChR	Others
J-104129 is a selective and orally active muscarinic M3 receptor antagonist (K_i = 4.2 nM). J-104129 is effective in promoting bronchodilation .

HY-107653

J 104129 fumarate	mAChR	Neurological Disease
J 104129 fumarate is a selective and orally active muscarinic M3 antagonist with K_i values of 4.2 nM and 490 nM for M3 and M2, respectively. J 104129 fumarate antagonized ACh-induced bronchoconstriction. J 104129 fumarate has the potential for the research of obstructive airway disease .

HY-149403

J-1048	Anaplastic lymphoma kinase (ALK)	Others
J-1048 is an activin receptor-like kinase 5 (ALK5) inhibitor. J-1048 can inhibit TAA-induced liver fibrosis in mice by explicitly blocking the TGF-β/Smad signaling pathway .

HY-118809

J 2931 NSC 321569; J 2532	Others	Others
J 2931 is an active compound.

HY-110216

5J-4	CRAC Channel	Inflammation/Immunology
5J-4 is a potent CRAC inhibitor. 5J-4 decreases the numbers of infiltrated mononuclear cell into the CNS, and significantly decreases the population of infiltrated CD4+ population. 5J-4 reduces the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in mouse model of inflammation .

HY-126873

Nikkomycin J	Others	Others
Nikkomycin J is an active compound. Nikkomycin J can be used for various researches .

HY-103360

J-113863 3 Publications Verification	CCR	Inflammation/Immunology
J-113863 is a potent and selective CCR1 antagonist with IC₅₀ values of 0.9 nM and 5.8 nM for human and mouse CCR1 receptors, respectively. J-113863 is also a potent antagonist of the human CCR3 (IC₅₀ of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC₅₀ of 460 nM). J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-α receptors. Anti-inflammatory effect .

HY-147648

Glyoxalase I inhibitor 6	Glyoxalase (GLO)	Cancer
Glyoxalase I inhibitor 6 (Compound 9j) is a glyoxalase I (Glo-I) inhibitor with an IC₅₀ of 1.13 μM. Glyoxalase I inhibitor 6 can be used as anticancer agent with low toxicity .

HY-149714

J6-3	ICMT	Cancer
J6-3 is an inhibitor of ICMT with an IC₅₀ of 0.6 μM and has anticancer activity. J6-3 inhibits MDA-MB231 cells with an IC₅₀ of 3.4 μM .

HY-13779A

J147	Monoamine Oxidase Dopamine Transporter	Neurological Disease
J147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. J147 can pass the blood brain barrier (BBB). J147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter. J147 plays an impotant role in Alzheimer’s disease (AD) .

HY-111615

J-2156	Somatostatin Receptor	Neurological Disease
J-2156 is a high potent, selective somatostatin receptor type 4 (SST4 receptor) agonist with IC₅₀s of 0.05 nM and 0.07 nM for human and rat SST4 receptors, respectively. J-2156 is used for the relief of mechanical allodynia and mechanical hyperalgesia in the ipsilateral hindpaws in rats .

HY-155699

J27644	HDAC	Inflammation/Immunology
J27644 is a potent HDAC inhibitor. J27644 mitigates TGF-β-induced pulmonary fibrosis .

HY-122021

J-115814	Neuropeptide Y Receptor	Neurological Disease
J-115814 is a potent and selective neuropeptide Y1 antagonist with K_i values of 1.4, 1.8, 1.9, >10000, 620, 6000, >10000 nM for hY1, rY1, mY1, hY2, hY4, hY5, mY6, respectively. J-115814 inhibits feeding behaviors .

HY-113366S

Prostaglandin J2-d4	Isotope-Labeled Compounds	Others
Prostaglandin J2-d₄ is the deuterium labeled Prostaglandin J2[1].

HY-N13315

Otophylloside J	Others	Neurological Disease
Otophylloside J is a pregnane glycosides isolated from the roots of Cynanchum otophyllum. Otophylloside J can be used in epilepsy research .

HY-N12137

Glycoside St-J	Others	Cancer
Glycoside St-J (Compound 2) is a triterpenoid saponin. Glycoside St-J has antitumor activity and inhibits HeLa cell proliferation. Glycoside St-J Isolates from natural Anemone flaccida. Glycoside St-J can be used in the development of new anticancer agents .

HY-119550

J1075	HDAC Parasite	Infection
J1075 is a selective Schistosoma mansoni HDAC8 inhibitor (with decreased affinity for human HDAC8). J1075 can induce apoptosis (Apoptosis) and death in schistosome cells. J1075 holds research value in the field of anti-parasitic agents .

HY-N9005

Dysolenticin J	Others	Cardiovascular Disease
Dysolenticin J has potent vasodilative effects on aortic rings. Dysolenticin J is an alkaloid that can be isolated from Dysoxylum lenticellatum .

HY-15648H

GSK-J5 hydrochloride	Others	Cancer
GSK-J5 hydrochloride is a cell-permeable ester derivative of GSK J2 (HY-15648A), inactive. GSK-J5 hydrochloride is also an isomer of GSK-J4 (HY-15648B) and often used as a negative group .

HY-157269

J10-1	Others	Inflammation/Immunology
J10-1 is a hapten. J10-1 promotes peptide exchange of all DR alleles (DR1, DR2, DR4 (DRB1*0401)) and promotes peptide binding to MHC II, which can be used in the study of immune regulation .

HY-N10899

Bruceine J	Parasite	Infection
Bruceine J, a quassinoid, is a nature product that could be isolated from fruits of Br. jaVanica. Bruceine J has anti-Babesial activity .

HY-116129

BPR1J-340	FLT3 Apoptosis	Cancer
BPR1J-340 is a potent FLT3 inhibitor with an IC₅₀ of ~25 nM. BPR1J-340 inhibits the phosphorylation of FLT3 and STAT5 and triggered apoptosis in FLT3-ITD ⁺ acute myeloid leukemia (AML) cells. BPR1J-340 exhibits significant anti-tumor activities .

HY-N9312

Ganoderic acid J	Others	Inflammation/Immunology
Ganoderic acid J is a natural terpenoid isolated from the Fungus Ganoderma lucidum. Ganoderic acid J possesses anti-inflammatory anti-inflammatory activity .

HY-N12812

Tenuifoliose J	Others	Neurological Disease
Tenuifoliose J is a neuroprotective oligosaccharide. Tenuifoliose J protects SY5Y cells induced by corticosterone (HY-B1618) .

HY-149713

J1-1	ICMT	Cancer
J1-1 is an inhibitor of ICMT with an IC₅₀ of 1.0 μM and has anticancer activity .

HY-112255

J9	Others	Cancer
J9 is a small molecule that reverses Dexamethasone (HY-14648) resistance in T-cell acute lymphoblastic leukemia. J9 is lethal to CUTLL1 cells only in the presence of Dexamethasone. J9 inhibits CUTLL1 cell growth with an EC₅₀ of 28 μM in combination with Dexamethasone .

HY-N12720

Cynanoside J	Others	Cancer
Cynanoside J is a C₂₁ steroidal glycosides that can be obtained from Cynanchum taihangense. The IC₅₀ values of Cynanoside J for HL-60, THP1, and Caco2 are 6.38, 5.82, and 6.76 μM, respectively. Cynanoside J can be used in cancer research .

HY-163535

J208	HDAC DNA Methyltransferase Apoptosis	Inflammation/Immunology Cancer
J208 is a dual inhibitor for histone deacetylase (HDAC) and DNA methyltransferase (DNMT). J208 inhibits proliferation of cancer cells, as well as the migration/invasion of triple-negative breast cancer (TNBC) cells. J208 induces apoptosis, arrests the cell cycle at G0/G1 phase. J2008 activates the innate immune signalling pathway in TNBC, by inducing the expression of endogenous retroviruses (ERVs) .

HY-124653

HSP27 inhibitor J2 5 Publications Verification J2	HSP	Cancer
HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition .

HY-125838

J30-8	JNK	Neurological Disease
J30-8 is a potent and isoform-selective inhibitor of c-Jun N-terminal kinase 3 (JNK3) with an IC₅₀ of 40 nM, which 2500-fold isoform selectivity against JNK1α1 and JNK2α2. J30-8 exhibits neuroprotective activity in vitro and potential for the treatment of neurodegenerative diseases .

HY-111615A

J-2156 TFA	Somatostatin Receptor	Neurological Disease Inflammation/Immunology
J-2156 TFA is a high potent, selective somatostatin receptor type 4 (SST₄ receptor) agonist with IC₅₀s of 0.05 nM and 0.07 nM for human and rat SST₄ receptors, respectively. J-2156 TFA has anti-inflammatory activity and it is used for the relief of mechanical allodynia and mechanical hyperalgesia in the ipsilateral hindpaws in rats .

HY-N7298

Derrisisoflavone J	Others	Others
Derrisisoflavone J is a natural product .

HY-N13575

Gancaonin J	Others
Gancaonin J is a natural product .

HY-N9670

Epimedonin J	Others	Others
Epimedonin J is a natural product .

HY-15648I

GSK-J2 sodium	Others	Cancer
GSK-J2 sodium is the sodium form of GSK-J2 (HY-15648A). GSK-J2 is an isomer of GSK-J1, and does not have any specific activity. GSK-J1 (HY-15648) is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A .

HY-N0786R

Ginkgolide J (Standard)	Others	Neurological Disease
Ginkgolide J (Standard) is the analytical standard of Ginkgolide J. This product is intended for research and analytical applications. Ginkgolide J is a main constituent of the non-flavone fraction of Ginkgo biloba with an IC₅₀ range of 12-54 μM, has neuroprotective and anti neuronal apoptotic ability .

HY-135008

J14 1 Publications Verification	Reactive Oxygen Species	Cancer
J14 is a reversible sulfiredoxin inhibitor with an IC₅₀ of 8.1 μM. J14 induces oxidative stress (intracellular ROS accumulation) by inhibiting sulfiredoxin, leading to cytotoxicity and cancer cell death .

HY-114072

J-113397	Opioid Receptor	Neurological Disease
J-113397 is the first potent and selective nonpeptidyl ORL1 receptor antagonist (K_i: cloned human ORL1=1.8 nM) without any agonistic effects on other opioid receptors .

HY-126556

Cytochalasin J	Microtubule/Tubulin	Cancer
Cytochalasin J is a cytochalasin detivative. Cytochalasin J affects mitotic spindel microtubule organization and kinetochore structure, and exhibits cytotoxicity in human leukemia K562 cell with IC₅₀ of 1.5 μM .

HY-13537A

BPR1J-097 Hydrochloride	FLT3	Cancer
BPR1J-097 Hydrochloride is a novel and potent FLT3 inhibitor with an IC₅₀ of 11 nM.

HY-13537

BPR1J-097	FLT3	Cancer
BPR1J-097 is a novel potent FLT3 inhibitor with an IC₅₀ of 11 nM.

HY-106140A

Asoprisnil ecamate J 956	Others	Others
Asoprisnil ecamate (J 956) is an orally active antiprogestin, and can be used for contraception .

HY-N6886

Rebaudioside J	Others	Others
Rebaudioside J is a diterpene glycoside that can be found in Stevia rebaudiana.

HY-N3930

Gardenoin J	Others	Cancer
Gardenoin J, a cycloartane triterpene, is isolated from the exudate of Gardenia thailandica.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N9312

Ganoderic acid J	Triterpenes Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Disease Research Fields Inflammation/Immunology	Others
Ganoderic acid J is a natural terpenoid isolated from the Fungus Ganoderma lucidum. Ganoderic acid J possesses anti-inflammatory anti-inflammatory activity .

HY-N13315

Otophylloside J	Structural Classification Polysaccharides Source classification Asclepiadaceae Cynanchum otophyllum Schneid． Plants Saccharides	Others
Otophylloside J is a pregnane glycosides isolated from the roots of Cynanchum otophyllum. Otophylloside J can be used in epilepsy research .

HY-N12137

Glycoside St-J	Triterpenes Structural Classification Anemone flaccida Fr. Schmidt Terpenoids Source classification Ranunculaceae Plants	Others
Glycoside St-J (Compound 2) is a triterpenoid saponin. Glycoside St-J has antitumor activity and inhibits HeLa cell proliferation. Glycoside St-J Isolates from natural Anemone flaccida. Glycoside St-J can be used in the development of new anticancer agents .

HY-N9005

Dysolenticin J	Triterpenes Structural Classification Dysoxylum lenticellatum C. Y. Wu ex H. Li Terpenoids Source classification Plants Meliaceae	Others
Dysolenticin J has potent vasodilative effects on aortic rings. Dysolenticin J is an alkaloid that can be isolated from Dysoxylum lenticellatum .

HY-N10899

Bruceine J	Structural Classification Simaroubaceae Terpenoids Source classification Diterpenoids Plants Brucea javanica (L.) Merr.	Parasite
Bruceine J, a quassinoid, is a nature product that could be isolated from fruits of Br. jaVanica. Bruceine J has anti-Babesial activity .

HY-N12812

Tenuifoliose J	Structural Classification Source classification Polygalaceae Phenols Polyphenols Plants Polygala tenuifolia Willd.	Others
Tenuifoliose J is a neuroprotective oligosaccharide. Tenuifoliose J protects SY5Y cells induced by corticosterone (HY-B1618) .

HY-N12720

Cynanoside J	Apocynaceae Structural Classification Cardiacglycosides Source classification Plants Vincetoxicum atratum (Bunge) Morren et Decne. Steroids	Others
Cynanoside J is a C₂₁ steroidal glycosides that can be obtained from Cynanchum taihangense. The IC₅₀ values of Cynanoside J for HL-60, THP1, and Caco2 are 6.38, 5.82, and 6.76 μM, respectively. Cynanoside J can be used in cancer research .

HY-N7298

Derrisisoflavone J	Structural Classification Flavonoids Leguminosae Source classification Derris trifoliata Lour. Plants Other Flavonoids	Others
Derrisisoflavone J is a natural product .

HY-N13575

Gancaonin J	Structural Classification Chalcones Flavonoids Glycyrrhiza pallidiflora Maxim. Leguminosae Source classification Plants	Others
Gancaonin J is a natural product .

HY-N9670

Epimedonin J	Structural Classification Source classification Phenols Polyphenols Epimedium brevicornu Maxim. Plants Berberidaceae	Others
Epimedonin J is a natural product .

HY-N0786R

Ginkgolide J (Standard)	Structural Classification Ginkgoaceae Terpenoids Source classification Diterpenoids Plants Ginkgo biloba	Others
Ginkgolide J (Standard) is the analytical standard of Ginkgolide J. This product is intended for research and analytical applications. Ginkgolide J is a main constituent of the non-flavone fraction of Ginkgo biloba with an IC₅₀ range of 12-54 μM, has neuroprotective and anti neuronal apoptotic ability .

HY-126556

Cytochalasin J	Structural Classification Natural Products Microorganisms Source classification	Microtubule/Tubulin
Cytochalasin J is a cytochalasin detivative. Cytochalasin J affects mitotic spindel microtubule organization and kinetochore structure, and exhibits cytotoxicity in human leukemia K562 cell with IC₅₀ of 1.5 μM .

HY-N6886

Rebaudioside J	other families Classification of Application Fields Terpenoids Source classification Other Diseases Diterpenoids Plants Disease Research Fields	Others
Rebaudioside J is a diterpene glycoside that can be found in Stevia rebaudiana.

HY-N3930

Gardenoin J	other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields Cancer	Others
Gardenoin J, a cycloartane triterpene, is isolated from the exudate of Gardenia thailandica.

HY-N7278

Mudanpioside J	Structural Classification Other Monoterpenes Monophenols Classification of Application Fields Terpenoids Source classification Other Diseases Phenols Plants Paeoniaceae Disease Research Fields Paeonia suffruticosa Andr.	Others
Mudanpioside J, a monoterpene glycoside, is a metabolite of cortex moutan .

HY-N12375

Kadsuphilin J	Structural Classification Source classification Phenols Polyphenols Kadsura philippinensis Elmer Plants Schisandraceae	Others
Kadsuphilin J is a lignan isolated from the roots of K. longipedunculata

HY-N10113

Verrucarin J Muconomycin B	Infection Natural Products Microorganisms Classification of Application Fields Marine algae Source classification Marine natural products Disease Research Fields	Apoptosis Arenavirus Fungal Antibiotic Reactive Oxygen Species
Verrucarin J (Muconomycin B) is a metabolite of the Myrothecium fungus family. Verrucarin J generates reactive oxygen species (ROS) and induces apoptosis of cancer cell lines, such as A549, HCT 116 and SW-620 cells. Verrucarin J shows activities against Candida albicans and Mucor miehei. Verrucarin J inhibits arenavirus Junin (JUNV) yield with an IC₅₀ of 1.2 ng/mL .

HY-N0385

Gomisin J 3 Publications Verification	Cardiovascular Disease Monophenols Classification of Application Fields Source classification Lignans Phenols Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill.	AMPK Calcium Channel
Gomisin J is a small molecular weight lignan found in Schisandra chinensis and has been demonstrated to have vasodilatory activity . Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca ²⁺/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells. gomisin J has potential benefits in treating nonalcoholic fatty liver disease .

HY-N8558A

Senkyunolide J	Structural Classification Natural Products Carlina acaulis L. Source classification Umbelliferae Plants	Others
Senkyunolide J, a phthalide, can be isolated from rhizome of Ligusticum Chuanxiong .

HY-N12802

Tenacissimoside J	Structural Classification Cardiacglycosides Marsdenia tenacissima (Roxb.) Moon Source classification Asclepiadaceae Plants Steroids	Others
Tenacissimoside J is a steroid glycoside and can be isolated from Marsdenia tenacissima .

HY-N10299

Guignardone J	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Endogenous Metabolite
Guignardone J is the secondary metabolite isolated from endophytic fungus Phyllosticta capitalensis .

HY-N8166

Celosin J	Triterpenes Structural Classification Celosia argentea Linn. Terpenoids Source classification Amaranthaceae Plants	Others
Celosin J is a natural compound that can be isolated from Celosia argentea seeds .

HY-N3767

Diosbulbin J	Structural Classification Terpenoids Source classification Diterpenoids Plants Dioscorea bulbifera Linn. Dioscoreaceae	Others
Diosbulbin J is a Diterpenoids product that can be isolated from the roots of Dioscorea bulbifera .

HY-N3370

Longipedlactone J	Triterpenes Structural Classification Kadsura heteroclita (Roxb.) Craib Terpenoids Source classification Plants Schisandraceae	Others
Longipedlactone J is a Triterpenoids product that can be isolated from the stems of Kadsura heteroclita. .

HY-126946

Nikkomycin pseudo-J	Structural Classification Natural Products Microorganisms Source classification	Fungal
Nikkomycin pseudo-J is a tripeptide derivative of the nikkomycin class found in Streptomyces tendae, which has antifungal and antiinsect activities. Nikkomycin pseudo-J exerts its biological activity by competitively inhibiting chitin synthetase of fungi and insects .

HY-N11781

Forrestiacids J	Triterpenes Structural Classification Classification of Application Fields Pinaceae Terpenoids Source classification Metabolic Disease Plants Pseudotsuga forrestii Craib Disease Research Fields	ATP Citrate Lyase
Forrestiacids J is an ATP-citrate lyase (ACL) inhibitor with an IC₅₀ of 2.6 μM .

HY-N7457

Decinnamoyltaxinine J	Structural Classification Terpenoids Taxaceae Source classification Diterpenoids Plants Taxus brevifolia Nutt.	Others
Decinnamoyltaxinine J is a Diterpenoids product that can be isolated from the leaves of Taxus brevifolia Nutt. .

HY-N10007

Dodoviscin J	Structural Classification Flavonoids Flavones Source classification Dodonaea viscosa (L.) Jacq. Sapindaceae Plants	Others
Dodoviscin J is a prenyl flavonol derivative can be isolated from the aerial parts of Dodonaea viscosa .

HY-N9250

Gentiside J	Structural Classification Gentiana rigescens Franch. ex Hemsl. Source classification Gentianaceae Phenols Polyphenols Plants	Others
Gentiside J is a Phenols product that can be isolated from the whole plants of Gentiana rigescens Franch. .

HY-119439

Lignan J1	Structural Classification Acanthaceae Source classification Lignans Justicia procumbens Linnaeus Phenylpropanoids Plants	Others
Lignan J1 is a lignan compound found in Justicia procumbens .

HY-N13294

Cernuumolide J TMJ-105	Structural Classification Terpenoids Carpesium cernuum L. Sesquiterpenes Source classification Plants Compositae	Apoptosis JAK STAT p38 MAPK JNK ERK
Cernuumolide J (TMJ-105) is an JAK2/STAT3 inhibitor. Cernuumolide J induces G2/M phase arrest and apoptosis in HEL leukemia cells by downregulating the phosphorylation of JAK2, STAT3, and Erk, and activating the phosphorylation of JNK and p38 MAPK. Cernuumolide J inhibits HEL leukemia cell growth in a time- and concentration-dependent manner, with an IC₅₀ value of 1.79 μM. Cernuumolide J can be used for research in the field of anti-cancer therapy .

HY-113366

Prostaglandin J2 PGJ2	Structural Classification Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Prostaglandin Receptor Endogenous Metabolite
Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with K_is of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC₅₀ value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimer's (AD) and Parkinson's diseases (PD) .

HY-N10588A

Nardoguaianone J 10-epi-Nardoguaianone K	Terpenoids Sesquiterpenes Nardostachys jatamansi (D. Don) DC. Plants Valerianaceae	Serotonin Transporter
Nardoguaianone J, a guaiane-type compound, can be isolated from Nardostachys chinensis roots. Nardoguaianone J can enhance SERT activity .

HY-N7460

7-Deacetoxytaxinine J	Structural Classification Taxus cuspidata Siebold & Zucc. Terpenoids Taxaceae Source classification Diterpenoids Plants	Others
7-Deacetoxytaxinine J is a Diterpenoids product that can be isolated from the heartwoods of Taxus cuspidata. .

HY-N7756

2-Deacetoxydecinnamoyltaxinine J	Structural Classification Natural Products Source classification Taxaceae Plants Taxus wallichiana Zucc.	Others
2-Deacetoxydecinnamoyltaxinine J is an active compound that can be isolated from Taxus cuspidta Sibe et Zucc .

HY-N0786

Ginkgolide J	Structural Classification Ginkgoaceae Terpenoids Source classification Diterpenoids Plants Ginkgo biloba	Others
Ginkgolide J is a main constituent of the non-flavone fraction of Ginkgo biloba with an IC₅₀ range of 12-54 μM, has neuroprotective and anti neuronal apoptotic ability .

HY-N7475

Taxinine J Cuspidatin C	Structural Classification Natural Products Source classification Taxaceae Taxus sumatrana (Miq.) de Laub. Plants	Others
Taxinine J (Cuspidatin C) is a natural compound isolated from the stem bark of Taxus sumatrana .

HY-N11008

Physagulide J	Structural Classification Source classification Physalis angulata L. Plants Solanaceae Steroids	Others
Physagulide J is a kind of withanolides compound that can be isolated from Physalis angulata L.. Many kinds of active ingredients of Physalis angulata L. shows anti-inflammatory and anti-tumor activity .

HY-N7734

2,7-Dideacetoxytaxinine J	Structural Classification Taxus cuspidata Siebold & Zucc. Terpenoids Taxaceae Source classification Diterpenoids Plants	Others
2,7-Dideacetoxytaxinine J is a Diterpenoids product that can be isolated from the heartwoods of Taxus cuspidata. .

HY-N7573

2-Deacetoxy-taxinine J	Structural Classification Taxus cuspidata Siebold & Zucc. Terpenoids Taxaceae Source classification Diterpenoids Plants	Others
2-Deacetoxy-taxinine J is a Diterpenoids product that can be isolated from the heartwoods of Taxus cuspidata. .

HY-N10292

Chaetosemin J	Infection Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields	Fungal Endogenous Metabolite
Chaetosemin J, an antifungal metabolite, exhibits inhibitory activity against plant pathogenic fungi Botrytis cinerea, Alternaria solani, Magnaporthe oryzae, and Gibberella saubinettii, with MIC values ranging from 12.5-25 μM .

HY-N11945

Schiarisanrin A Kadsulignan J	Structural Classification Source classification Lignans Phenylpropanoids Plants Kadsura coccinea (Lem.) A. C. Smith Schisandraceae	NO Synthase
Schiarisanrin A (Kadsulignan J) is a lignan with inhibitory activity on NO production. Schiarisanrin A inhibits NO production in BV-2 cells with an IC₅₀ of 9.6 μM .

HY-N3903

Forskolin J 6-Acetylforskolin; 6-O-Acetylforskolin	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Plants Pueraria montana (Lour.) Merr.	Others
Forskolin J (6-Acetylforskolin) is a product that can be isolated from .

HY-122949

Momordicine I	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Plants Momordica charantia Linn.	DGK
Momordicine I, a triterpenoid compound extracted from momordica charantia L. Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ .

HY-N10432

Xanthine oxidase-IN-8 Icarisids J	Flavonols Flavonoids Juglandaceae Source classification Cyclocarya paliurus (Batal.) Iljinsk. Plants	Xanthine Oxidase
Xanthine oxidase-IN-8 (Icarisids J) (Compound 7) is a XOD inhibitor with an IC₅₀ of 29.71 μM .

HY-N12370

Tenaxin I	Structural Classification Flavonoids Flavones Labiatae Source classification Plants Medicago truncatula Gaertn.	Others
Tenaxin I is a component extracted from Radix Scutellariae with neuraminidase inhibitory activity .

HY-N2545

Tenacissoside X Tenacissoside J	Classification of Application Fields Source classification Marsdenia tenacissima (Roxb.) Moon Asclepiadaceae Plants Disease Research Fields Inflammation/Immunology Steroids	Others
Tenacissoside X (Tenacissoside J) is a compound isolated from Marsdenia tenacissima. Marsdenia tenacissima, a traditional Chinese herbal medicine, has long been used for the research of asthma, tracheitis, rheumatism, etc .

HY-108568R

15-Deoxy-Δ-12,14-prostaglandin J2 (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	PPAR Endogenous Metabolite
15-Deoxy-Δ-12,14-prostaglandin J2 (Standard) is the analytical standard of 15-Deoxy-Δ-12,14-prostaglandin J2. This product is intended for research and analytical applications. 15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC₅₀ of 2 μM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC₅₀ of 7 μM .

HY-15194

Dimethylcurcumin 10+ Cited Publications ASC-J9; GO-Y025	Zingiber officinale Roscoe Structural Classification Classification of Application Fields Simple Phenylpropanols Source classification Phenylpropanoids Plants Disease Research Fields Zingiberaceae Cancer	Androgen Receptor
Dimethylcurcumin (ASC-J9) is an androgen receptor degradation enhancer that effectively suppresses castration resistant prostate cancer cell proliferation and invasion.

HY-N12073

Monofucosyllacto-N-hexaose I MFLNH I	Structural Classification Polysaccharides Animals Source classification Saccharides	Others
Monofucosyllacto-N-hexaose I (MFLNH I) is a composition of human milk oligosaccharide .

Cat. No.	Product Name	Chemical Structure

HY-108568S

15-Deoxy-Δ-12,14-prostaglandin J2-d4

15-Deoxy-Δ-12,14-prostaglandin J2-d₄ is the deuterium labeled 15-Deoxy-Δ-12,14-prostaglandin J2. 15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM[1][2].

HY-W019776

Sudan I-d5
Sudan I-d₅ is a the deuterated Sudan I. Sudan I is a diazo-conjugate red dye and can be used as an additive to products such as oils, solvents or polishes. Sudan I inhibits growth of bacterial strains Clostridium perfringens and L. rhamnosus[1].

HY-B1411S

i-Inositol-d6
i-Inositol-d₆ is the deuterium labeled i-Inositol. i-Inositol is a chemical compound, associated lipids are found in many foods, in particular fruit, especially cantaloupe and oranges.

HY-113366S

Prostaglandin J2-d4
Prostaglandin J2-d₄ is the deuterium labeled Prostaglandin J2[1].

HY-117743S1

Eprosartan-d6
Eprosartan-d₆ is deuterated labeled Eprosartan (HY-117743). Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensin II receptor with IC₅₀s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .

HY-W890109S

Spiramycin I-d3-1
Spiramycin I-d₃-1 is deuterium-labeled Spiramycin I .

HY-143623S

Neo Spiramycin I-d3
Neo Spiramycin I-d₃is the deuterium labeledNeo Spiramycin I(HY-143623) . Neo Spiramycin I (NSPI) is the active metabolite of Spiramycin (SPI) with antimicrobial activity. Neo Spiramycin is widely used in veterinary medicine .

HY-124211S

Dibenzo(a,i)pyrene-d14
Dibenzo(a,i)pyrene-d₁₄ is the deuterium labeled Dibenzo(a,i)pyrene[1].

HY-W008452S

H-Tyr(3-I)-OH-13C6
H-Tyr(3-I)-OH- ¹³C₆ is the ¹³C-labeled H-Tyr(3-I)-OH. H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite[1][2].

HY-B1411S1

i-Inositol-d1
i-Inositol-d is the deuterium labeled i-Inositol[1].

HY-B0175S

Toltrazuril-d3
Toltrazuril-d₃ is deuterated labeled Toltrazuril. Toltrazuril (BAY-i 9142) is an antiprotozoal agent that acts upon Coccidia parasites.

HY-P1032S1

Angiotensin I-13C5,15N (human, mouse, rat)

Angiotensin I- ¹³C₅, ¹⁵N (human, mouse, rat) is the ¹³C and ¹⁵N labeled Angiotensin I (human, mouse, rat) (HY-P1032). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice .

HY-P1032S

Angiotensin I-13C19,15N3 (human, mouse, rat)

Angiotensin I- ¹³C₁₉, ¹⁵N₃ (human, mouse, rat) is the ¹³C and ¹⁵N labeled Angiotensin I (human, mouse, rat) (HY-P1032). Cellulose (Pectin glycosidase) is a natural high molecular weight polysaccharide found in many plants and organisms. It is widely used in manufacturing industries, such as in paper making, textiles, food and medicine, etc. As a renewable resource, Cellulose is biodegradable and sustainable, and can also be used to manufacture chemicals such as Cellulose Esters, Cellulose Acetate and Cellulose Nitrate. In addition, Cellulose is often used as a food additive to increase the stability and quality of food .

HY-117743S

Eprosartan-d3
Eprosartan-d₃ is the deuterium labeled Eprosartan. Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensin II receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively [1].

HY-W010452S1

3-Hydroxybutyric acid-13C4 sodium
3-Hydroxybutyric acid- ¹³C₄ (sodium) is the ¹³C labeled 3-Hydroxybutyric acid sodium (HY-W010452). 3-Hydroxybutyric acid sodium is a metabolite that is elevated in type I diabetes, and can modulate the properties of membrane lipids[1].

HY-W010452S2

3-Hydroxybutyric acid-13C2 sodium
3-Hydroxybutyric acid- ¹³C₂ (sodium) is the ¹³C labeled 3-Hydroxybutyric acid sodium (HY-W010452). 3-Hydroxybutyric acid sodium is a metabolite that is elevated in type I diabetes, and can modulate the properties of membrane lipids[1].

HY-18600AS

Azimilide-d8 dihydrochloride
Azimilide-d₈ (dihydrochloride) is the deuterium labeled Azimilide dihydrochloride. Azimilide Dihydrochloride (NE-10064 Dihydrochloride) is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes.

HY-117743AS1

Eprosartan-d6 hydrochloride
Eprosartan-d₆ hydrochloride is deuterated labeled Eprosartan.

HY-16562S1

Irinotecan-d10 hydrochloride
Irinotecan-d₁₀ (hydrochloride) is the deuterium labeled Irinotecan. Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex[1][2].

HY-16562S

Irinotecan-d10
Irinotecan-d₁₀ is a deuterium labeled Irinotecan ((+)-Irinotecan). Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex[1].

HY-B0374S1

Moxonidine-d7
Moxonidine-d₇ is deuterated labeled Moxonidine (HY-B0374). Moxonidine (BDF5895) is an imidazoline type 1 receptor (I1-R) selective agonist and antihypertensive agent.

HY-W008820S

Glutaric acid-d6 1 Publications Verification
Glutaric acid-d₆ is the deuterium labeled Glutaric acid. Glutaric acid is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I[1][2][3].

HY-B0374AS

Moxonidine-13C,d3 hydrochloride
Moxonidine- ¹³C,d₃ hydrochloride is ¹³C and deuterated labeled Moxonidine hydrochloride (HY-B0374A). Moxonidine (BDF5895) hydrochloride is an imidazoline type 1 receptor (I1-R) selective agonist and antihypertensive agent.

HY-W008820S1

Glutaric acid-d4
Glutaric acid-d₄ is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I[1][2][3].

HY-W008820S2

Glutaric acid-d2
Glutaric acid-d₂ is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I[1][2][3].

HY-160219S

BTK-IN-33
BTK-IN-33 is a Btk inhibitor with anticancer effects (WO2023174300A1; compound I) .

HY-160220S

KRAS inhibitor-23
KRAS inhibitor-23 (Isomer 2 of compound i) is a potent inhibitor of KRAS that plays an important role in cancer research .

HY-13631AS

Exatecan-d5 mesylate
Exatecan-d₅ (mesylate) is deuterium labeled Exatecan mesylate. Exatecan mesylate is a DNA topoisomerase I inhibitor, with an IC50 of 0.975 μg/mL[1].

HY-13566AS

Belotecan-d7 hydrochloride
Belotecan-d₇ (hydrochloride) is the deuterium labeled Belotecan hydrochloride. Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative[1][2].

HY-16560S

Camptothecin-d5

Camptothecin-d₅ is the deuterium labeled Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM[1]. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells[2][3].

HY-110363

Miglustat-d9 hydrochloride
Miglustat-d₉ (hydrochloride) is the deuterium labeled Miglustat (hydrochloride). Miglustat hydrochloride is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1)[1][2].

HY-17020S

Miglustat-d9
Miglustat-d9 is the deuterium labeled Miglustat. Miglustat (N-Butyldeoxynojirimycin) is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1) .

HY-16562AS

Irinotecan-d5 hydrochloride
Irinotecan-d₅ hydrochloride is deuterated labeled Irinotecan hydrochloride (HY-16562A). Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer .

HY-12383S

Pelubiprofen-13C,d3

Pelubiprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Pelubiprofen. Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects[1].

HY-113005S

Glutarylcarnitine-d9 chloride
Glutarylcarnitine-d₉ (chloride) is the deuterium labeled Glutarylcarnitine chloride. Glutarylcarnitine is the diagnostic metabolite for malonic aciduria and glutaric aciduria type I monitored in most tandem mass spectrometry newborn screening programmes.

HY-N0733S2

Glucosamine-13C,15N hydrochloride
Glucosamine- ¹³C, ¹⁵N (hydrochloride) is the ¹³C and ¹⁵N labeled Glucosamine hydrochloride. Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, i

HY-W020033S

Lanosterol-d6
Lanosterol-d₆ is deuterium labeled Lanosterol. Lanosterol is an intermediate of cholesterol synthesis and use of lanosterol induces ubiquitination and degradation of a rate-controlling enzyme of cholesterol synthesis, i.e., HMG CoA reductase. Lanosterol s

HY-W012382S

N-Acetyl-L-tyrosine-d3
N-Acetyl-L-tyrosine-d₃ is the deuterium labeled N-Acetyl-L-tyrosine. N-Acetyl-L-tyrosine originates from tyrosine through an AA acetylase, is associated with aromatic L-amino acid decarboxylase deficiency and tyrosinemia I.

HY-50856S

Deuruxolitinib
Deuruxolitinib, a deuterated Ruxolitinib (HY-50856), modulates the activity of JAK1/JAK2. Deuruxolitinib can be used for the research hair loss disorders (from patent WO2017192905A1, compound I) .

HY-13631DS

Dxd-d5
Dxd-d₅ is a deuterium labeled Dxd. Dxd is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a) [1].

HY-12163S

Entinostat-d4
Entinostat-d₄ is the deuterium labeled Entinostat[1]. Entinostat is an oral and selective class I HDAC inhibitor, with IC50s of 243 nM, 453 nM, and 248 nM for HDAC1, HDAC2, and HDAC3, respectively[2].

HY-101392S

Harmane-d1

Harmane-d is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively)[1][2][3][4].

HY-101392S1

Harmane-d2

Harmane-d₂ is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively)[1][2][3][4].

HY-113378S

3-Hydroxybutyric acid-d4 sodium
3-Hydroxybutyric acid-d₄ (sodium) is the deuterium labeled 3-Hydroxybutyric acid. 3-Hydroxybutyric acid (β-Hydroxybutyric acid) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid can modulate the properties of membrane lipids[1].

HY-W008351S

L-Ribose-13C
L-Ribose- ¹³C is the ¹³C labeled L-Ribose. L-Ribose, a non-naturally occurring pentose, is an ideal starting material for use in synthesizing L-nucleosides analogues. Many anticancer and antiviral agents are synthesized based on a backbone of L-Ribose and i

HY-109015S

Tucidinostat-d4
Tucidinostat-d₄ is the deuterium labeled Tucidinostat. Tucidinostat is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, respectively[1].

HY-13955S1

Telmisartan-d4
Telmisartan-d₄ is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM[1][2].

HY-B0109S

Dorzolamide-d5
Dorzolamide-d₅ is the deuterium labeled Dorzolamide. Dorzolamide (L671152) is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity[1][2].

HY-13955S

Telmisartan-d3
Telmisartan-d₃ is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM[1][2].

HY-W010452S

3-Hydroxybutyric acid-d2 sodium
3-Hydroxybutyric acid-d₂ (sodium) is the deuterium labeled 3-Hydroxybutyric acid sodium[1]. 3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid sodium can modulate the properties of membrane lipids[2].

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